CoA
Objectives

1. To determine outcomes for neonates with coarctation of the aorta.
2. To analyze the importance of different treatment strategies.

From 1990 to 1993, 893 neonates with CoA were enrolled prospectively from 32 institutions.

Note: There is no follow-up phase being conducted for this cohort.

PAIVS & PSIVS

PAIVS Objectives:

1. To determine the proportion of neonates reaching defined end-states (i.e. Bi-ventricular Repair, Fontan, Heart Transplant, One-and-a-half ventricle repair or death).
2. To identify risk factors associated with end-state, including Bi-ventricular Repair Fontan, Heart Transplant, One-and-a-half ventricle repair or death).

From January 1987 to April 1997, 408 neonates with PAIVS admitted to a CHSS institution within 30 days after birth were prospectively enrolled in a multi-institutional study.
PAIVS was defined as no communication between the right ventricle (RV) and pulmonary trunk and absence of ventricular septal defect (VSD) as determined by echocardiographic, catheterization, or surgical findings.

PSIVS Objectives:

1. To determine outcomes and associated patient and management factors for neonates with pulmonary stenosis with intact ventricular septum.
2. To observe the transition from surgical to percutaneous management.

From 1987 to 1997, 448 neonates with PAIVS or PSIVS were enrolled prospectively from 33 institutions.

IAA

Objectives

1. To determine outcomes for neonates with interruption of the aortic arch (IAA).
2. To determine what patient management variables improve outcomes.

From 1987 to 1997, 470 neonates with IAA were enrolled prospectively from 33 institutions.

TGA

Objectives:

1. To assemble a multi-institutional inception cohort of neonates with Transposition of the Great Arteries.
2. To compare survival outcomes of neonates age 2 weeks presenting with various forms of TGA.

From 1985 to 1989, 890 neonates with TGA were enrolled from 24 institutions.